Bioengineering

Our Bioengineering core comprises projects tackling a specific translational problem relevant to drug development. Expected outcomes are new tools, assays or instruments (not validated) enabling translation, as well proof of concept for drug development application.

Meet the team

The Microtechnologies group focuses on developing microengineering tools — including microfluidics, optics, and mechatronics — to culture and analyse biological systems ranging from single cells to organoids and tumour explants. In synergy with other IHB groups, these microengineered devices will help create in vitro models closer to in vivo conditions and thus better predicting drug efficacy and safety. In collaboration with other pRED groups, we aim to develop a suite of standalone microtechnologies that can be used in various translational applications or earlier in the drug discovery pipeline.

Eleonore Cauquil

Research Associate

Philip Dettinger

Postdoctoral Researcher

Janosch Hauser

Postdoctoral Researcher

Hannah Theresa Kronabitter

Research Associate

Barbora Lavickova

Postdoctoral Researcher

Mar Cervera Negueruela

Research Fellow

Iago Pereiro

Scientist

Ludwig Pollich

Senior Research Associate
Group Lead: Matthias P. Lütolf

Despite breakthrough advances in generating physiologically relevant organoid models, challenges remain in implementing real-life applications in drug discovery and development. A major problem is that conventional organoid models consist of only a single tissue, usually the epithelium, and therefore lack tissue-tissue interactions that play a key role in the development, maturation and physiological function of an organ, as well as in disease. We are exploring novel approaches to increase tissue-tissue complexity in organoids, and we are also investigating intact patient-derived tissue explants as an experimental model system, particularly in the context of solid tumours. We anticipate that these next-generation multi-tissue systems will better mimic the biology of human organs and diseases.

Matthias P. Lütolf

Group Lead and Head of Translational Bioengineering

Audrey Bender

Research Fellow

Sarah Egger

Research Fellow

Mehmet Girgin

Postdoctoral Researcher

Rosan Hans

PhD Student

Yanyan Hou

Senior Research Associate

Tania Jetzer

Senior Research Associate

Youngmin Jo

Postdoctoral Researcher

Rok Krese

PhD Student

Sebastian Loskarn

Research Associate

Elisa Marani

PhD Student

Olga Mitrofanova

Postdoctoral Researcher

Jyoti Rao

Senior Scientist

Giuliana Rossi

Senior Scientist
Group Lead: Nikolche Gjorevski

Organoids hold great promise in modelling human development and diseases. Owing to missing cell types and compartments, they have yet to live up to their billing as mini-organs and significantly benefit translational research and patients.

In collaboration with IHB and Roche Pharmaceutical Research and Early Development (pRED) researchers, the Organoid Engineering group aims to increase the (patho)physiological likeness of organoids to healthy and diseased organs by combining insights from high-dimensional phenotyping with spatially and temporally controlled multicellular engineering.

Areas of focus include introducing tissue-specific stromal and immune compartments and engineering immune responses.

Katerina Apostolopoulou

Senior Research Associate

Julien Aubert

Research Associate

Adrian Mihai Filip

Research Associate

Régine Gérard

Lab Manager/Principal Research Associate

Tinotenda Gwisai

Postdoctoral Researcher

Marius Harter

PhD Student

Kristina Kromer

PhD Student

Stephanie Münchau

Postdoctoral Researcher

Mikhail Nikolaev

Postdoctoral Researcher

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