Publications

IHB scientists actively participate in the global scientific community not only through collaboration and partnership, but also through sharing their work in peer-reviewed publications.

Quan Xu, Barbara Treutlein, Fabian J. Theis, Gray Camp and colleagues

An integrated transcriptomic cell atlas of human endoderm-derived organoids

A new paper led by Quan Xu (IHB) and Lennard Halle (Helmholtz Munich), and additional lead scientists at IHB, Roche pRED, ETH Zurich and Helmholtz Munich, and their collaborators, have built detailed atlases of brain, gut, and lung organoids. These atlases now allow researchers to compare the organoids’ cells across labs, protocols, and to patient samples, including those that will be collected and studied in the future.

Joep Beumer, Hans Clevers, Ninouk Akkermann and colleagues

Description and functional validation of human enteroendocrine cell sensors

A new research paper by Joep Beumer, IHB Group Lead of Organoid Gene Editing, and Hans Clevers, Head of Roche pRED and ad interim IHB Director, identified rare enteroendocrine cells within the gut that release hormones involved in metabolism. They used intestinal organoids to identify so called nutrient sensors and their function. This may point to potential new avenues for therapeutics for metabolism-related disorders.

Timothy Recaldin, Linda Steinacher, Bruno Gjeta, Marius F Harter and colleagues

Human organoids with an autologous tissue-resident immune compartment

A new research paper by scientists in IHB and Roche pRED’s Immunology create innovative intestinal organoids with tissue-integrated immune cells, extending their utility beyond epithelium-centered questions and applications. The model recapitulates intestinal inflammation triggered by cancer immunotherapies, providing detailed insight into the underlying mechanisms.

Olga Mitrofanova and colleagues

Bioengineered human colon organoids with in vivo-like cellular complexity and functionality

A new research paper by Olga Mitrofanova, IHB Postdoctoral Scientist, and colleagues from IHB, Roche pRED’s Pharmaceutical Sciences and EPFL’s School of Life Sciences, describe a new “organoid-on-a-chip” system that merges stem cell biology and innovation in bioengineering to better represent organs for research and development. It offers unprecedented insight into how medicines & drug candidates act on our human body – an understanding fundamental to successful drug development.

1234/4