Our Computational Biology core, to launch in August 2025, will complement existing Roche R&D capabilities in computational sciences in the development of computational approaches that will specifically advance IHB’s mission of advancing human model systems for academic and pharmaceutical research. Expected outcomes are innovative AI/ML tools and simulation approaches to inform the quantitative and mechanistic interpretation of data acquired by the experimental teams at IHB.
This group, effective August 2025, will focus on developing an integrated computational and experimental framework to decipher the causal interactions between transcriptional, molecular, metabolic, and morphological regulation of single cell function during organoid development and response to therapy. The computational branch of the group will apply simulation and methods of causal inference to decipher the nonlinear interactions between these regulatory layers. The experimental branch will synergize with the groups in the Exploratory Biology and Translational Bioengineering Cores on performing experiments at the single cell level that will generate key data not already available in IHB to inform computational model building. Of particular interest will be experiments testing the roles of cell morphogenesis as an input to rather than merely the result of organoid regulation.
We are always looking for talented individuals.