IHB science spotlight: Organoid Co-Culture Systems: New Frontiers in Immune-Organ Interactions Immune-organoid model systems may be the next frontier in organoid technology. By creating controlled, patient-specific micro-environments, these models provide critical mechanistic insights into immune-driven diseases and offer a high-fidelity platform for evaluating the safety and efficacy of next-generation immunotherapies. The intricate relationship between the immune […]

IHB science spotlight: Mapping the complex landscape of human cell types By leveraging emerging experimental and computational techniques, scientists suggest that we can gain valuable insight into the causal relationships between perturbation and cell state, potentially providing mechanistic insight of development or identifying drug targets. Scientists envision a future where we can predict a cell’s […]

IHB science spotlight: Patient-derived Organoids Predict Safety of Cancer Immunotherapies Scientists leveraged donor-matched intestinal organoids of healthy tissues and tumoroids of cancerous tissue, along with immune cells, to capture and scrutinize the inflammatory-like toxicities T-cell-engaging bispecific antibodies (TCBs) may induce. This innovative approach is poised to accelerate the development of safer and efficacious drugs for […]