IHB science spotlight: Organoid Co-Culture Systems: New Frontiers in Immune-Organ Interactions Immune-organoid model systems may be the next frontier in organoid technology. By creating controlled, patient-specific micro-environments, these models provide critical mechanistic insights into immune-driven diseases and offer a high-fidelity platform for evaluating the safety and efficacy of next-generation immunotherapies. The intricate relationship between the immune […]

IHB faces of innovation: Elisabeth Gill and Stephanie Münchau Schöpp The success of IHB owes much to the wonderful and inspiring people who work in its labs. We are featuring Elisabeth Gill, Scientist, and Stephanie Schoepp, Postdoctoral Researcher, both part of the IHB Organoid Engineering team. “I am excited about the increasing use of bio-engineered […]

IHB InSight: Kidney organoids This image is part of the IHB InSight series, featuring compelling scientific images of the latest innovative human model systems work done by IHB scientists. For more images, go to our News feed. Kidney organoids represent a powerful and versatile in vitro platform that is significantly accelerating research into fundamental kidney […]

IHB InSight: Small intestine This image is part of the IHB InSight series, featuring compelling scientific images of the latest innovative human model systems work done by IHB scientists. For more images, go to our News feed. ´Oral drugs need to be designed so that a therapeutic dose can be absorbed in the gut and […]

IHB faces of innovation: Bruno Gjeta The success of IHB owes much to the wonderful and inspiring people who work in its labs. We are featuring Bruno Gjeta, who is the first student to receive his PhD at IHB and works in the Developmental Systems and Computational Biology team. “Since childhood, I have always been […]

IHB InSight: Colorectal tumour organoids This image is part of the IHB InSight series, featuring compelling scientific images of the latest innovative human model systems work done by IHB scientists. For more images, go to our News feed. ´IHB I.S. (InSight): A constellation of organoids derived from colorectal cancer tissue. These organoids were generated from […]

IHB faces of innovation: Mar Cervera Negueruela The success of IHB owes much to the wonderful and inspiring people who work in its labs. We are featuring here R&D engineer Mar Cervera Negueruela, who works in the Microtechnologies team. “I have always been fascinated by technology: how we can automate processes, design prototypes and build […]

IHB InSight: hiPSC-derived astrocytes This image is part of the IHB InSight series, featuring compelling scientific images of the latest innovative human model systems work done by IHB scientists. For more images, go to our News feed. ´This image shows mature astrocytes of the central nervous system that were derived from human induced pluripotent stem […]

IHB science spotlight: Mapping the complex landscape of human cell types By leveraging emerging experimental and computational techniques, scientists suggest that we can gain valuable insight into the causal relationships between perturbation and cell state, potentially providing mechanistic insight of development or identifying drug targets. Scientists envision a future where we can predict a cell’s […]

IHB science spotlight: Patient-derived Organoids Predict Safety of Cancer Immunotherapies Scientists leveraged donor-matched intestinal organoids of healthy tissues and tumoroids of cancerous tissue, along with immune cells, to capture and scrutinize the inflammatory-like toxicities T-cell-engaging bispecific antibodies (TCBs) may induce. This innovative approach is poised to accelerate the development of safer and efficacious drugs for […]