Postdoctoral Fellow – Metabolic homeostasis

Basel, Switzerland

The position

In Roche’s Pharmaceutical Research and Early Development organisation (pRED), we make transformative medicines for patients in order to tackle some of the world’s toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicines. Together, we create a culture defined by curiosity, responsibility and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed.

You will join Roche’s Institute of Human Biology, an organization within pRED whose goal is to harness and advance the use of human model systems in drug discovery and development, as well as personalized medicine. Our interdisciplinary research bridges academic and pharmaceutical research, connecting biologists, engineers, and data scientists.

We partner and collaborate with leading scientific institutions worldwide to tackle grand challenges by assembling, funding, and leading interdisciplinary teams of experts to work on highly ambitious and complex scientific questions.

Job mission

We are offering an outstanding opportunity for a talented scientist to contribute to our mission to disrupt the traditional drug discovery process. You will be responsible for exploring novel mechanistic biology in the area of metabolic homeostasis. Of particular interest is the goal to understand the mechanism by which adipose tissue interacts with other tissues to mediate whole-body energy homeostasis, disruption of which results in diabetes. You will be mentored by the Group Lead of the Metabolic Homeostasis team at IHB. You will hence benefit from existing IHB know-how and innovative technologies in performing your translational research (microtechnologies and bioengineering methods, organoids expertise, phenotyping and phenoscaping capabilities). You will also be supported by a network of experts in pRED and Roche with clinical experience in the metabolic disease area as you explore patient-relevant scientific hypotheses.

This role involves independently driving the development of multicellular in vitro systems for modeling interactions between adipose tissue and sensory neurons. Collaborating with experts across different disciplines, you will build accurate models of sensory innervation and its functional consequences. You will plan, execute, and document experiments, analyze data, and present results. Additionally, you will liaise with colleagues to find synergies and supervise/train personnel and students when needed. Understanding the pRED drug development process is important to identify therapeutic opportunities.

Your impact

  • Enhances the drug discovery process by developing more predictive human model systems.
  • Utilizes state-of-the-art 3D cell culture technologies and stem cells to create advanced adipose organoid models.
  • Aims to replicate the intricate functions of white adipose tissue in vitro, and to improve the study of fat biology.
  • Compares organoid models to native tissue to ensure physiological accuracy and relevance.
  • Offers the potential to significantly impact public health by informing the development of novel therapeutics for metabolic conditions.

Your profile

You thrive in a dynamic, inclusive environment which gives you full accountability for your own contributions and development. You are resourceful and flexible in problem-solving and working in a collaborative and inclusive manner. Furthermore, you are dedicated to establishing a culture of mutual support, cross-training, continuous learning and self-organization to meet project and functional goals.

Preferred start date of the Postdoc is May 2024, or upon availability, for a duration of three years. Please clearly indicate your preferred starting date on your motivation letter.

To be considered your application needs to include a cover letter, a CV (including a list of relevant publications) and the names of three references.

Our commitment

Roche commits to recognising talent and aptitude. We prioritize encouraging and supporting our employees in their personal journeys by providing a safe, creative space to help them reflect, make decisions and grow in their career. We are confident that we find the most innovative solutions by gaining different perspectives, asking and answering hard questions, and challenging the status quo. Roche embraces diversity and equal opportunity in a serious yet enthusiastic way; we are devoted to building a team that represents a range of backgrounds, perspectives, and skills. The more inclusive we are, the better our work will be.

Who we are

At Roche, more than 100,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.

Besides extensive development and training opportunities, we offer flexible working options, 18 weeks of maternity leave and 10 weeks of gender independent partnership leave. Our employees also benefit from multiple services on site such as child-care facilities, medical services, restaurants and cafeterias, as well as various employee events.

We believe in the power of diversity and inclusion, and strive to identify and create opportunities that enable all people to bring their unique selves to Roche.

Roche is an Equal Opportunity Employer.