Postdoctoral Fellow (m/f/d) – Institute of Human Biology, Multiple Myeloma in vitro Modeling

Basel/Zurich, Switzerland

The position

In Roche’s Pharmaceutical Research and Early Development organisation (pRED), we make transformative medicines for patients in order to tackle some of the world’s toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicines. Together, we create a culture defined by curiosity, responsibility and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed.

You will join Roche’s Institute of Human Biology, an organisation within pRED whose goal is to harness and advance the use of human model systems in drug discovery and development, as well as personalised medicine. Our interdisciplinary research bridges academic and pharmaceutical research, connecting biologists, engineers, and data scientists.

We partner and collaborate with leading scientific institutions worldwide to tackle grand challenges by assembling, funding, and leading interdisciplinary teams of experts to work on highly ambitious and complex scientific questions.

Job mission

We are offering an outstanding opportunity for a talented scientist to contribute to our mission to disrupt the traditional drug discovery process by advancing more predictive human model systems. You will be responsible for establishing a patient-derived preclinical ex vivo model of multiple myeloma (MM) with key components of the tumor microenvironment. Of particular interest is the goal to recreate the immunosuppressive microenvironment that is a hallmark of MM and to extend the duration of culture of bone marrow aspirates from MM patients. You will be mentored by the Scientific Director of the Roche Institute of Human Biology, as well as a Group Lead and a full member of the Applied Organoid Technologies team at IHB. You will hence benefit from existing IHB know-how and innovative technologies to guide your model development and translational research (microtechnologies and bioengineering methods, organoids expertise, phenotyping and phenoscaping capabilities). Supported by a network of experts in pRED and Roche with clinical experience in this disease area, you will explore patient-relevant scientific hypotheses to test in the model(s) developed and will leverage this knowledge to improve and validate the assays.

Your profile

The preferred start date of the PostDoc is October 2023, or upon availability, for a duration of two years. Please clearly indicate your preferred starting date on your motivation letter. The position could be based in Basel or Schlieren (Great Zürich area) depending on the candidate’s preference.

To be considered your application needs to include a cover letter, a CV (including a list of relevant publications) and the names of three references.

Our commitment

Roche commits to recognising talent and aptitude. We prioritize encouraging and supporting our employees in their personal journeys by providing a safe, creative space to help them reflect, make decisions and grow in their career. We are confident that we find the most innovative solutions by gaining different perspectives, asking and answering hard questions, and challenging the status quo. Roche embraces diversity and equal opportunity in a serious yet enthusiastic way; we are devoted to building a team that represents a range of backgrounds, perspectives, and skills. The more inclusive we are, the better our work will be.

Who we are

At Roche, more than 100,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.

Besides extensive development and training opportunities, we offer flexible working options, 18 weeks of maternity leave and 10 weeks of gender independent partnership leave. Our employees also benefit from multiple services on site such as child-care facilities, medical services, restaurants and cafeterias, as well as various employee events.

We believe in the power of diversity and inclusion, and strive to identify and create opportunities that enable all people to bring their unique selves to Roche.

Roche is an Equal Opportunity Employer.

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